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	<title>Comments on: On Not De-Extincting Homo neanderthalensis</title>
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	<link>http://blogs.law.stanford.edu/lawandbiosciences/2013/02/18/on-not-de-extincting-homo-neanderthalensis/</link>
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		<title>By: hgreely</title>
		<link>http://blogs.law.stanford.edu/lawandbiosciences/2013/02/18/on-not-de-extincting-homo-neanderthalensis/comment-page-1/#comment-108408</link>
		<dc:creator>hgreely</dc:creator>
		<pubDate>Fri, 22 Feb 2013 18:08:24 +0000</pubDate>
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		<description>Thanks for the compliment.  And your question is a great one.  Some researchers have recently concluded that at least some modern humans may have as much as 2 to 3 percent of their DNA with sequences found in Neanderthals but not otherwise in modern humans.  These Neanderthal sequences have not been found in sub-Saharan Africans, leading people to conclude that their inclusion in non-African modern humans is probably the result of interbreeding between &quot;out of Africa&quot; modern humans and Neanderthals.  But this is all somewhat uncertain.  

Of course, there are other sequence variations that are found in modern humans and in Neanderthals - and chimps, monkeys, mice, fruit flies, etc.  I suppose one way of asking your last question would be whether all the DNA sequences (or almost all?) found in the Neanderthals we have sequenced (a handful, at most) can also be found among modern humans.  If so, one could imagine (very difficult in practice, of course) &quot;backbreeding&quot; with modern humans to get a child born of modern humans that had an entirely Neanderthal DNA sequence.  I guess I would still say the Neanderthals are &quot;extinct&quot; but that they could be revived without genetic engineering.   

I would be very surprised if all the Neanderthal-specific sequences can be found in modern humans, but i don&#039;t know - and I don&#039;t know whether it is only 2 to 3 percent of Neanderthal-specific (or, probably more accurately, &quot;Neanderthal present; modern human not (very) present&quot;) genetic variations that have been found in (some) modern (non-African) humans or 20 to 30 percent or 80 to 90 percent.  My guess is toward the lower end, but I&#039;ll ask some experts.</description>
		<content:encoded><![CDATA[<p>Thanks for the compliment.  And your question is a great one.  Some researchers have recently concluded that at least some modern humans may have as much as 2 to 3 percent of their DNA with sequences found in Neanderthals but not otherwise in modern humans.  These Neanderthal sequences have not been found in sub-Saharan Africans, leading people to conclude that their inclusion in non-African modern humans is probably the result of interbreeding between &#8220;out of Africa&#8221; modern humans and Neanderthals.  But this is all somewhat uncertain.  </p>
<p>Of course, there are other sequence variations that are found in modern humans and in Neanderthals &#8211; and chimps, monkeys, mice, fruit flies, etc.  I suppose one way of asking your last question would be whether all the DNA sequences (or almost all?) found in the Neanderthals we have sequenced (a handful, at most) can also be found among modern humans.  If so, one could imagine (very difficult in practice, of course) &#8220;backbreeding&#8221; with modern humans to get a child born of modern humans that had an entirely Neanderthal DNA sequence.  I guess I would still say the Neanderthals are &#8220;extinct&#8221; but that they could be revived without genetic engineering.   </p>
<p>I would be very surprised if all the Neanderthal-specific sequences can be found in modern humans, but i don&#8217;t know &#8211; and I don&#8217;t know whether it is only 2 to 3 percent of Neanderthal-specific (or, probably more accurately, &#8220;Neanderthal present; modern human not (very) present&#8221;) genetic variations that have been found in (some) modern (non-African) humans or 20 to 30 percent or 80 to 90 percent.  My guess is toward the lower end, but I&#8217;ll ask some experts.</p>
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		<title>By: Dr. David Perry</title>
		<link>http://blogs.law.stanford.edu/lawandbiosciences/2013/02/18/on-not-de-extincting-homo-neanderthalensis/comment-page-1/#comment-108407</link>
		<dc:creator>Dr. David Perry</dc:creator>
		<pubDate>Fri, 22 Feb 2013 17:40:52 +0000</pubDate>
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		<description>Fascinating issue, Hank.  And your analysis is enviably wise and thorough, especially for a short essay like this.  A couple of technical questions:  Does Neanderthal DNA remain in some of us today?  If so, should we then say that Neanderthals did not actually become extinct?</description>
		<content:encoded><![CDATA[<p>Fascinating issue, Hank.  And your analysis is enviably wise and thorough, especially for a short essay like this.  A couple of technical questions:  Does Neanderthal DNA remain in some of us today?  If so, should we then say that Neanderthals did not actually become extinct?</p>
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